our Research
Telephone:
+44 (0)1865 613271
email:
darragh.ennis@bioch.ox.ac.uk
We are interested in understanding how the fly brain develops and functions, as a model for the human brain in health and in disease.
Lab Members
METhods & Technology development
Contact Us
Address:
Biochemistry Dept.,
University of Oxford,
South Parks Rd.,
Oxford,
OX1 3QU
Vacancies &
PhD Positions
Research Focus
We are interested in understanding how the fly brain develops and functions, as a model for the human brain in health and in disease. We are focusing on elucidating the role of post-transcriptional regulation of gene expression in neural stem cell (neuroblast) development and their differentiation into neurons, as well as in synaptic plasticity during memory and learning. These mechanisms include mRNA transport and localised translation, as well as mRNA stability and processing.
Keywords: mRNA, Neuronal development, Neural stem cells, Drosophila, live cell imaging, synaptic plasticity, neuromuscular junction, brain, neurons, memory, learning, neuromuscular diseases.
We use a wide range of methodologies in our research, from established methods to cutting edge technologies and purpose-built microscopes.
Movies & Images
- Yang L., Titlow J., Ennis D., Smith C., Mitchell J., Young F.L., Waddell S., Ish-Horowicz D., Davis I. (2017) Single molecule fluorescence in situ hybridisation for quantitating post-transcriptional regulation in Drosophila brains. Methods. pdf
- Yang L., Samuels T.J., Arava Y., Robertson F., Järvelin A.I., Yang C-P., Lee T., Ish-Horowicz D., Davis I. (Under Review, Cell Reports) Regulating prospero mRNA Stability Determines When Neural Stem Cells Stop Dividing. pre-print
- Yang C-P, Samuels TJ, Huang Y, Yang L, Ish-Horowicz D, Davis I, Lee T. (2017). Imp/Syp Temporal Gradients Govern Decommissioning Of Drosophila Neural Stem Cells. Development. 144(19):3454-3464 pdf.
- Hailstone M., Yang L., Waithe D., Samuels T.J., Arava Y., Dobrzycki T., Parton R.M., Davis I. (Under Review, Dev Cell) Brain Development: Machine Learning Analysis Of Individual Stem Cells In Live 3D Tissue. pre-print
- Moore S., Jarvelin A.I., Davis I., Bond G.L., Castello, A. (2017) Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer. Current Opinion in Genetics and Development. (In press)
- Titlow JS, Yang L, Parton RM, Palanca A, Davis I. (2017) Super-Resolution Single Molecule FISH at the Drosophila Neuromuscular Junction. Methods Mol Biol. 1649:163-175. pdf
Full list of publications on Pubmed
We welcome informal enquiries from prospective Post-Doc and PhD students
The research in our lab is generously funded by Wellcome, the Leverhulme Trust, the BBSRC and Marie Curie.
Recent Publications
Browse a selection of movies and still images taken using the advanced imaging techniques we use in the lab.
RNA - what is it and what does it do?
We are particularly interested in how RNA is involved in the development of the nervous system and memory & learning. But what is RNA? The DNA that is in every one of our cells contains vast amounts of information (genes) used as instructions to make proteins. When a cell needs to make a protein this part of the DNA is copied and the copy is called RNA. These are then sent to the cell machinery in order for a protein to be made. Of particular interest to us are RNAs located at the distant end of nerve cells that are used to enable quick growth of nerves and synapses a long way from the cell nucleus. In order to study these tiny molecules we use cutting-edge microscopy techniques.
Plain English
Fruit Flies
In the Davis lab we use fruit flies to study how the nervous system works on a microscopic level. These are the same fruit flies commonly seen in kitchens in the summertime. Perhaps surprisingly, fruit flies are very similar to humans in how they control the function of their cells, making them an excellent model system to use. The fly nervous system works in essentially the same way as it does in mammals, with the same types of nerves as well as a distinct brain with similar structures to those found in a human brain.
In the Davis lab we have a team of people from diverse scientific backgrounds who bring a wide range of skills to our research.