Carine Meignin

Aino Jarvelin

Wellcome Trust Postdoctoral Researcher


mRNA localisation and cellular learning



jonathan.harrison@st-hughs.ox.ac.uk

I am studying for my DPhil as part of the Systems Biology DTC programme. My background is in mathematics and I use computational models and inference techniques to enable us to elucidate the key parts and rate-limiting steps in mRNA localisation. 

Former Members

2008-2014


RNA localisation and its effect on oocyte development



Lab Manager/Senior Wellcome Trust Postdoctoral Researcher




richard.parton@bioch.ox.ac.uk


I work using state-of-the-art and advanced imaging techniques as well as developing improved imaging methods and quantitative image analysis to investigate the molecular mechanism of RNA transport in Drosophila tissues. 

While in the Davis lab, Carine worked on various aspects of RNA localisation and how different aspects, including localisation signals and interactions with molecular motors, influenced axis specification. She now heads the RNAi & Receptors research group at  the Réponse immunitaire et développement chez les Insectes in the IBMC in Strasbourg.



Josh Titlow

Jeff Lee

System Biology DPhil Student

 

Mathematical modelling of

mRNA transport in egg

chambers during axis

specification

 

ONBI DPhil Student


Machine learning image analysis tools development



snt29@cornell.edu


Staci worked on screening the Drosophila brain for novel localising RNAs with a particular emphasis on studying the molecular mechanisms of activity-dependent synaptic plasticity in the axons of the mushroom body. She now works in the Neurobiology Dept. of Cornell University. 

ilan.davis@bioch.ox.ac.uk


Professor of Cell Biology

Wellcome Trust Senior Research Fellow 
Senior Research Fellow, Jesus College

Director, Micron Oxford 





rsh46@cam.ac.uk


Russell developed bioinformatic methods in our lab to analyse RNA structural motifs and how they impacted on RNA localisation and protein interactions. He is now a senior bioinformatician at the Centre for Trophoblast Research in Cambridge.

Wellcome Trust Postdoctoral Researcher / Bioinformatician


Genomics analysis of post-transcriptional regulation


ana.palanca@bioch.ox.ac.uk

I joined the Davis lab to investigate the role of neuronal granules in synaptic plasticity and memory, using the larvae of Drosophila as a model.

darragh.ennis@bioch.ox.ac.uk


I am Ilan's lab manager and I also work on a large-scale screen seeking new RNA targets that localise in the Drosophila nervous system. The tissue I am working on is the larval brain.

lu.yang@hmc.ox.ac.uk


Lu worked on RNA regulation in neural stem cells using a combination of biochemical and microscopy analysis to uncover the molecular mechanisms for differentially regulated protein expressions in different cell types in the context of neural development.

Russell 

Hamilton

Suzanne 

McDermott

DPhil student / Post-doctoral

clinical training


RNA regulation in neural stem cells





Senior Wellcome Trust Postdoctoral Researcher


Microtubule dynamics and advanced imaging



Wellcome Trust DPhil Student


Control of neurogenesis in the Drosophila larval brain






2009 - 2014


Syncrip and the Drosophila neuromuscular junction

2016 - 2017


Activity dependent mushroom body development



2005-2014


Computational biology and structural analysis.





tamsin.samuels@chch.ox.ac.uk

I am in the Davis lab working in the Wellcome Trust Chromosome and Developmental Biology D. Phil. programme. My research is on trying to understand changes in the transcriptome caused by the switch from proliferation to differentiation of larval brain stem cells in Drosophila.

tw419@cam.ac.uk


Tim worked on the influence the localisation of certain RNAs, particularly bicoid and gurken, has on Drosophila development. He currently is a lab head in Cambridge Zoology Dept, where his group work on RNA localisation and egg activation. 

jeff.lee@sjc.ox.ac.uk


I am interested in how post-transcriptional mechanisms govern neural stem cell proliferation and differentiation during brain development. Particularly, I will focus on the cis and trans-acting factors acting through highly extended 3'UTR in transcript regulations. 

mary.thompson@bioch.ox.ac.uk

The development of the brain requires a complex series of cell fate decisions, frequently involving transcriptional regulation of key factors. I am interested in assessing how post-transcriptional processes contribute to the precise timing and outcome of these developmental transitions.

martin.hailstone@linacre.ox.ac.uk


Large imaging datasets can be difficult to analyse in an efficient and consistent manner. I am working on developing flexible tools for imaging and the subsequent analysis of Drosophila larval brains to better understand their development.

Kirsty Sholem

francesca.robertson@bioch.ox.ac.uk

Here in the Davis lab I work on how phosphorylation influences the function of Syncrip, a critical gene of interest in our lab that is heavily involved in neurogenesis.

staci Thornton

Ana Palanca

2012-2017


A structure function analysis of gurken mRNA





RicharD PArton

Marie Curie Postdoctoral Fellow


The role of post-transcriptional regulation in brain development


Dphil Students

ilan Davis

MK Thompson

JONATHAN HARRISON

Tamsin Samuels

James Halstead

Gavin Wilkie: 1998-2001. Dynein-mediated RNA transport in Drosophila oocytes.

Gavin went on to work on human disease research and diagnostics and currently is the facility manager of the Next-Generation sequencing facility at the University of Glasgow.


Hille Tekotte: 1999-2002. Nuclear export and its impact on Drosophila development

After graduating, Hille went on to work in a protein biology lab under Michael Tyers, and is currently the manager of the Edinburgh Genome Foundry at the University of Edinburgh.


Nina McDougall: 2000-2003. gurken localisation and axis specification in the Drosophila oocyte.


​Alejandra Clarke: 2001-2005. The mechanism  of gurken mRNA transport and localisation .


​Georgia Vendra: 2002-2006. mRNA localisation in Drosophila blastoderm embryos.

After a short postdoctoral stint in the lab, Georgia went on to work at the Centre for Brain Research at the Medical University of Vienna, where she is currently a staff scientist.


Jan Soetaert: 2004-2008. mRNA localisation and localisation in p-bodies.

​Jan currently works as a staff scientist in the imaging facility of the Blizard Institute, a part of Queen Mary's University.


Suzanne McDermott: 2005-2009. The signals required for gurken localisation. 

For information on Suz's postdoc work in our lab, see above.


Sam Cooper: 2007-2010. Proteomic analysis of factors binding gurken.

Sam now works as an administrator at Gonville & Caius college in Cambridge.


James Maximillian Halstead: 2009-2013. Regulation of translation and localisation by Syncrip.

For more information on James see his profile above. 


Alex Davidson: 2011-2015. Localised translation of gurken and it's control by orb

Alex has joined a consultancy firm since leaving the lab. 


Lu Yang: 2013-2016. RNA regulation in neuroblasts.

Lu is currently a medical student while also working part-time in our lab. For more information see her profile, above. 


Kirsty Sholem: 2013-2017.The structure of the gurken localisation signal.

Kirsty worked with us as a postdoc for several months (see above), before leaving the lab to pursue a career in teaching. 






2006-2012


RNA localisation and axis specification in Drosophila development .





Suzanne worked on how Syncrip regulates other key synaptic proteins in order to form synapses at the neuromuscular junction. She currently works in the Centre for Infectious Disease Research in Seattle, WA. 

Biochemistry DPhil Student


The role of post-transcriptional regulation in brain development



aino.jarvelin@bioch.ox.ac.uk


In the Davis lab, I combine experimental, sequencing based techniques and bioinformatic data analysis to elucidate how RNA-binding proteins regulate neural stem cell differentiation.I also work together with the Castello lab on characterising the roles of RNA-binding proteins in viral infection.

Darragh Ennis

Lu Yang

Fran Robertson

Marie Curie Postdoctoral Fellow


Phosphorylation effects on syncrip function




MArtin Hailstone

2009-2013


Syncrip and the morphology of the neuromuscular junction 





Former Students

joshua.titlow@bioch.ox.ac.uk

In the Davis lab I am investigating how specific RNA molecules behave near synapses during the process of cellular learning.

Tim Weil

Group Leader




Wellcome Trust Postdoctoral Researcher


Electron and super-resolution microscopy






ILAN DAVIS LAB
OXFORD



While in the Davis lab,  James worked on one of the key genes that we are interested in, Syncrip. He worked on how Syncrip is involved in signalling and plasticity at synapses. He left the lab to work with Jeffrey Chao in Basel and is currently a senior postdoctoral fellow in Katherina Gaus' lab in New South Wales.



Kirsty worked how Gurken becomes localised to its final destination at the dorsal-anterior corner of Drosophila oocytes, a key part of the developmental process. She now taken up a teaching role.