Lu worked as a postdoctoral researcher in the Davis Lab, having completed my PhD here in 2016. Lu started her PhD in Oxford in 2012 and continued on with her research which involves working cell fate of brain stem cells after she graduated. She has since left the lab and is currently pursuing a medical degree.
My PhD and current postdoctoral work focused on the role of RNA regulation in neural stem cells. Brain development is a complex event that depends on the precise regulation of the balance between neural stem cell proliferation and differentiation. Neuroblasts asymmetrically divide and give rise to two daughter cells. The fate of the two daughter cells depends on the expression level of specific protein regulators. However, how the expression level of these protein regulators is regulated in different cell types remains largely unknown. I used a combination of biochemical and microscopy analysis to uncover the molecular mechanisms for differentially regulated protein expressions in different cell types in the context of neural development.
Tel: 01865 613271
Above: Some examples of Drosophila larval brain images that I use to study RNA regulation. We use sophisticated in situ hybridisation techniques to image single molecules of RNA
Left: A typical Canadian Summer at Queen's University
Yang L, Titlow J, Ennis D, Smith C, Mitchell J, Young FL, Waddell S, Ish-Horowicz D, Davis I. (2017) Single molecule fluorescence in situ hybridisation for quantitating post-transcriptional regulation in Drosophila brains. Methods.
Yang L, Samuels TJ, Arava Y, Robertson F, Järvelin AI, Yang C-P, Lee T, Ish-Horowicz D, Davis I. (2017) Regulating prospero mRNA Stability Determines When Neural Stem Cells Stop Dividing. In Press
Yang C-P, Samuels TJ, Huang Y, Yang L, Ish-Horowicz D, Davis I, Lee T. (2017). Imp/Syp Temporal Gradients Govern Decommissioning Of Drosophila Neural Stem Cells. Development. 144(19):3454-3464.
McDermott SM, Yang L, Halstead JM, Hamilton RS, Meignin C, Davis I. (2014) Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junction. RNA. 2014 Oct;20(10):1593-606
I completed a BSc in Life Science degree at Queen’s University, Canada followed by a Masters in Neuroscience degree at Oxford. I previously worked on studying the brain at a system and behavioural level. It is very interesting to be studying similar problems but from very different perspectives.
Outside work, I try to go for a long bike ride or a run whenever I can. I also enjoy music greatly and currently playing with the Oxford University Orchestra.