ILAN DAVIS LAB
OXFORD


Tamsin Samuels


I have recently completed my DPhil in the Davis lab working on the role of post-transcriptional regulation in neurogenesis. This was part of the Wellcome Trust Chromosome and Developmental Biology DPhil programme at Oxford and I am also a member of Christ Church college. I also enjoy baking and cycling in my free time.


Current Project


I am interested in the role of post-transcriptional regulation in neurogenesis, a process so far mainly attributed to transcriptional changes. The switch between proliferation and differentiation must be tightly controlled in the stem cells of the brain. In the Davis Lab we are using the Drosophila third instar larval brain as a model for this process. I am exploring how post-transcriptional regulation, mediated by RNA binding proteins, influences these cell fate decisions. To answer this question I am using a combination of microscopy (including immunofluorescence and fluorescence in situ hybridisation), and biochemistry (such as RNA immunoprecipitations and RNA sequencing).



Above: Fixed in situ hybridisation images of Drosophila larval brains, showing  glial cells expressing GFP (left), miranda antibody staining in the optic lobe (centre), and prospero FISH in the entire brain.

Publications


Yang L, Samuels TJ, Arava Y, Robertson F, Järvelin AI, Yang C-P, Lee T, Ish-Horowicz D,   Davis I. (2017) Regulating prospero mRNA Stability Determines When Neural Stem Cells Stop Dividing. In Press


Yang C-P, Samuels TJ, Huang Y, Yang L, Ish-Horowicz D, Davis I, Lee T. (2017). Imp/Syp Temporal Gradients Govern Decommissioning Of Drosophila Neural Stem Cells. In Press


Previous Work


Before coming to Oxford I studied at the University of Cambridge (Newnham College), completing a BA in Natural Sciences in 2013, followed by an MSci in Biochemistry in 2014. For my Masters project I worked in Dr Simon Bullock's lab in the MRC Laboratory of Molecular Biology, exploring the localisation of mRNAs in the dendritic arborisation neurons of the Drosophila larva.


I joined the Wellcome Trust Chromosome and Developmental Biology DPhil programme at the University of Oxford in 2014 and completed rotation projects in the Davis lab and in Professor Rob Klose's Lab, also in the Biochemistry Department. In the Klose lab I worked on the establishment and epigenetic maintenance of Polycomb domains in mouse embryonic stem cells. I joined the Davis lab to start my full DPhil project in 2015.

Contact Details

Tel: 01865 613271

tamsin.samuels@chch.ox.ac.uk